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\hypersetup{pdftitle={Wound Healing Activity of Dried Leaves of some Selected Plants on Excision Wound in Rabbits},pdfauthor={Oluwabunmi Bolarin, Adebayo Oni, Chryss Onwuka, Jimoh Olanite},pdfsubject={Tropentag 2018: Abstract},pdfkeywords={Aspilia africana, Azadirachta indica, Moringa oleifera, Rabbit, wound Healing},pdfpagemode=None,colorlinks=true}
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\parbox[b]{13.4cm}{\centering \large{\textbf{Tropentag, September 17-19, 2018, Ghent}}\\[1ex] \Large{``Global food security and food safety:\\The role of universities''\\[2ex]}}
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\begin{center}
\Large{\textbf{Wound Healing Activity of Dried Leaves of some Selected Plants on Excision Wound in Rabbits\footnote{\textbf{Contact Address:} Oluwabunmi Bolarin, Federal University of Agriculture, Animal Nutrition, Alabata, 110011~Abeokuta, Nigeria, \mbox{e-mail}: \email{bolarinoluwabunmi@yahoo.com}}\\[0.8ex]}}
\normalsize{\textsc{Oluwabunmi Bolarin$^{1}$, Adebayo Oni$^{2}$, Chryss Onwuka$^{3}$, Jimoh Olanite$^{4}$}}
\end{center}
\begin{itemize*}
\item[]{\small{\textit{$^{1}$Federal University of Agriculture, Animal Nutrition, Nigeria}}}
\item[]{\small{\textit{$^{2}$Federal University of Agriculture, Abeokuta, Dept. of Animal Nutrition, Nigeria}}}
\item[]{\small{\textit{$^{3}$Federal University of Agriculture, Abeokuta, Dept. of Animal Nutrition, Nigeria}}}
\item[]{\small{\textit{$^{4}$Federal University of Agriculture, Abeokuta, Pasture and Range Management, Nigeria}}}
\end{itemize*}
\index[author]{Bolarin, Oluwabunmi}
\index[author]{Oni, Adebayo}
\index[author]{Onwuka, Chryss}
\index[author]{Olanite, Jimoh}
\begin{center}
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\textbf{Abstract}
\begin{abstract}
\normalsize{
Healing of a wound is a complex and protracted process of tissue repair and remodelling in response to injury. The aim of treating wounds is to both hasten their healing and preclude undesirable consequences that may arise in the process. Plant products of \textit{Azadirachta indica}, Aspilia africana and \textit{Moringa oleifera} are cheap, locally available and safer than conventional wound therapies and they may provide a viable alternative to expensive conventional wound remedies especially for poor communities in developing countries. Leaves of these plants are used traditionally for medicinal purpose, which shows anti"=inflammatory, immune"=modulatory, anti"=carcinogenic, blood purifier and wound healing properties. The proposed study was conducted according to the guidelines for care and use of animals. Treatment I is the control diet, Treatment II and III represent \mbox{15\,\%} and \mbox{30\,\%} \textit{Moringa oleifera} meal, Treatment IV and V represent \mbox{15\,\%} and \mbox{30\,\%} Aspilia africana meal, Treatment VI and VII represent \mbox{15\,\%} and \mbox{30\,\%} \textit{Azadirachta indica} meal respectively. Twenty- one grower rabbits of both sexes were used for the study. Wounds were inflicted on the rabbits using a punch- excision model of \mbox{2.5\,cm} diameter and treated with the test ingredients to evaluate and compare the influence of the plant material on wound healing. Healing was assessed by percentage wound contraction and microbial counts. All experimental rabbits were fed on daily basis for 24 days and wound area measurements were taken every three days.



Significant ($p > 0.05$) differences were not observed at the 1\textsuperscript{st}, 3rd and 24\textsuperscript{th} day of post wounding. Rabbits on \mbox{15\,\%} Aspilia africana meal and \mbox{15\,\%} \textit{Azadirachta indica} meal had better wound healing activity from 6\textsuperscript{th} to 24\textsuperscript{th} day of post wounding compared to other treatments. High total bacteria and coliform counts (6.15\,$\times$\,\unitfrac[106]{cfu}{ml} and 3.35\,$\times$\,\unitfrac[106]{cfu}{ml}) were recorded in rabbits fed \mbox{30\,\%} \textit{Moringa oleifera} meal compared to \mbox{30\,\%} Aspilia Africana meal  (5.05\,$\times$\,\unitfrac[106]{cfu}{ml} and 2.80\,$\times$\,\unitfrac[106]{cfu}{ml}) and \textit{Azadirachta indica} meal (5.50\,$\times$\,\unitfrac[106]{cfu}{ml}   and 3.10\,$\times$\,\unitfrac[106]{cfu}{ml}) respectively. The study has indicated that \mbox{15\,\%} Aspilia africana and \textit{Azadirachta indica} meals accelerate wound healing which suggests good potentials for use in wound care.



}

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\end{abstract}
\end{center}
\noindent \textbf{Keywords:} Aspilia africana, \textit{Azadirachta indica}, \textit{Moringa oleifera}, Rabbit, wound Healing
\index[key]{Aspilia africana}
\index[key]{Azadirachta indica@\textit{Azadirachta indica}}
\index[key]{Moringa oleifera@\textit{Moringa oleifera}}
\index[key]{Rabbit}
\index[key]{Wound Healing}
\end{document}
